Selling expensive items

Just wondering about how other sellers go about selling expensive items? What is the best way to safeguard yourself when you do sell something in the $1000's. My average sales are possibly around $2-300 with some up to $1000.

 

With the rules around having to have a "safe payment method" how do others protect themselves selling something for say $4000+?

 

I have a few things I am considering selling that are around the above figure, but with things as they are on eBay heavily weighted in favour of buyers, what are some ways that other sellers can suggest to protect yourself from scammers, chargebacks etc...?