Im always happy to deal with new Customers / Buyers. 

Ive never had many problems with them at all . I treat everyone the same whether they are a 0 feedback or 5000+ and buy a $5 item or a $1000 one. Treat them with respect and as though they are all an important customer , which of course they are , sometimes they need talking through certain steps and a bit of cuddling to get their confidence and understanding up to speed. 

What ive found over the years is that newbie buyers that have a great 1st up experience with you will always come back later on.