I would try not running non-essential processes first.

How often do you turn your computer off? Despite the naysayers who say it isn't possible, I find that after a few days my computer tends to slow down. Rebooting seems to fix the issue, so that's what I do. I dunno if it is clogged RAM or not, but it works.

I have 16Gb or RAM, but I have no idea how that rates for capacity these days.