I dont have any restrictions on the countries I post to and most of the time things go OK. I only have slightly higher problems with OS post than sending within Australia. I dont sell items which are likely to attract scammers and most of my customers are pretty genuine and need the item, rather than discretionary spends. This probably helps. The items I sell cost me very little, but often have mark ups of 500%-1000%, so I can afford to lose the occasional one and really only lose the postage cost. 

I add an extra $1 to international postage costs as self insurance and this covers any occasional problems.. International sales make up around 25% of my sales and often take the more unusual items that may have a restricted market within Australia. Basically it depends on what you sell, but unrestricted international sales can be useful if you view ebay as a business, are willing to play the odds and dont take it all too personally.